2013国际抗癫痫联合会抗癫痫药用指南
2022-03-23 12:25 来源:吕梁男科医院
hepurposeofthisreportwastoupdatethe2006InternationalLeagueAgainstEpilepsy(ILAE)reportandidentifythelevelofevidenceforlong-termefficacyoreffectivenessforantiepilepticdrugs(AEDs)asinitialmonotherapyforpatientswithnewlydiagnosedoruntreatedepilepsy.AllapplicablearticlesfromJuly2005untilMarch2012wereidentified,evaluated,andcombinedwiththepreviousysis(Glauseretal.,2006)toprovideacomprehensiveupdate.
Thepriorysismethodologywasutilizedwiththreemodifications:(1)thedetectablenoninferiorityboundaryapproachwasdroppedandbothfailedsuperioritystudiesandprespecifiednoninferioritystudieswereyzedusinganoninferiorityapproach,(2)thedefinitionofanadequatecomparatorwasclarifiedandnowincludesanabsoluteminimumpointestimateforefficacy/effectiveness,and(3)therelationshiptablebetweenclinicaltrialratings,levelofevidence,andconclusionsnolongerincludesarecommendationcolumntoreinforcethatthisreviewofefficacy/evidenceforspecificseizuretypesdoesnotimplytreatmentrecommendations.
Thisevidencereviewcontainsoneclarification:ThecommissionhasdeterminedthatclassIsuperioritystudiescanbedesignedtodetectuptoa20?solute(ratherthanrelative)differenceinthepointestimateofefficacy/effectivenessbetweenstudytreatmentandcomparatorusinganintent-to-treatysis.SinceJuly,2005,threeclassIrandomizedcontrolledtrials(RCT)and11classIIIRCTshebeenpublished.Thecombinedysis(1940-2012)nowincludesatotalof64RCTs(7withclassIevidence,2withclassIIevidence)and11meta-yses.
Newefficacy/effectivenessfindingsincludethefollowing:levetiracetamandzonisamidehelevelAevidenceinswithpartialonsetseizuresandbothethosuximideandvalproicacidhelevelAevidenceinchildrenwithchildhoodabsenceepilepsy.
Therearenomajorchangesinthelevelofevidenceforanyothersubgroup.LevetiracetamandzonisamidejoincarbamazepineandphenytoinwithlevelAefficacy/effectivenessevidenceasinitialmonotherapyforswithpartialonsetseizures.AlthoughethosuximideandvalproicacidnowhelevelAefficacy/effectivenessevidenceasinitialmonotherapyforchildrenwithabsenceseizures,therecontinuestobeanalarminglackofwelldesigned,properlyconductedepilepsyRCTsforpatientswithgeneralizedseizures/epilepsiesandinchildreningeneral.
Thesefindingsreinforcetheneedformulticenter,multinationaleffortstodesign,conduct,andyzefutureclinicallyrelevantadequatelydesignedRCTs.Whenselectingapatient'sAED,allrelevantvariablesandnotjustefficacyandeffectivenessshouldbeconsidered.
查看信源地址
编辑:jiang-
治疗急性浅表性龟头炎用什么药好
治疗急性浅表性龟头炎用什么药好呢?其实和其他的龟头炎类型相较为,浅表性龟头炎还算是不太常见的,可是这种类型的龟头炎万一呈现伤害也是最大的...[详细]
标签:
2019-10-25
-
男性原发性早泄的病发该怎么办
原发性早泄是现在临床上发病率较高的一种男性病症,也相信提到原发性早泄,足以令每个男性朋友闻之色变,原发性早泄不仅让男性患者的身心健康受...[详细]
标签:
2019-10-18
-
原发性早泄的检查诊断方式
对第一次性交早泄过分忧虑,或许加重心理负担,形成紧张、早泄、更紧张、继续早泄的恶性循环而使早泄固定下来。神经衰弱时由于大脑的抑制能力减...[详细]
标签:
2019-10-16
-
治疗原发性早泄应当用什么方式
相信大家对原发性早泄这一男科病症应当都不会太过生疏了吧,原发性早泄是现在生活中发病率非常高的一种,给每个患者都带来了非常大的伤害,专家...[详细]
标签:
2019-10-16
-
男性睾丸炎的保健措施是什么
男性患者有着身心双重打击和伤害。专家意见,男性睾丸炎要及早察觉并进行专业的诊断和治疗。并且,日常生活中还应当重视睾丸炎保健。哪么,睾丸...[详细]
标签:
2019-10-11
-
前列腺炎是什么因素诱发
前列腺炎是怎么诱发的?患有前列腺炎的男性越来越多,可是较多前列腺炎患者对这一问题并不是看,因此在治疗的时候也产生了很大的难度,给患者带...[详细]
标签:
2019-10-08
-
预防龟头炎的重视事项有那些
据调查表明,在临床上,龟头炎的发病率越来越高,这是一种威胁男性健康的常见病症,俗话说预防大于治疗,与其得了病症想尽办法去治疗,不如及早...[详细]
标签:
2019-10-07